New York Giants wide receiver Hakeem Nicks is expected to miss at least three weeks with compartment syndrome in his right leg, the team announced on Monday.

Compartment syndrome is a serious condition that involves increased pressure in a muscle compartment. It can lead to muscle and nerve damage and problems with blood flow.

Nicks was injured during the Giants' 27-17 loss to the Philadelphia Eagles on Sunday night.

A first-round pick in 2009, Nicks leads the Giants with 62 receptions for 800 yards and 9 touchdowns. With Steve Smith out for another week or two with a partially-torn pectoral muscle, the Giants are down to Mario Manningham and Derek Hagan as their starting wide receivers.

The Giants host the Jacksonville Jaguars on Sunday.